For semaglutide, the majority of GI side effects are mild to moderate in severity and of short duration. “Gastrointestinal (GI) events are well-known side effects of the GLP-1 class. In response to CNN’s request for comment, Novo Nordisk, maker of Ozempic and Wegovy, pointed out that drugs in this class have been used for 15 years to treat diabetes and for eight years to treat obesity, and they have been extensively studied in the real world and in clinical trials. (Photo illustration by Mario Tama/Getty Images) Mario Tama/Getty ImagesĮuropean regulator expands investigation into risks of suicidal thoughts in users of popular weight-loss medications Some doctors prescribe Ozempic off-label to treat obesity. ![]() In recent months, there has been a spike in demand for Ozempic, or semaglutide, due to its weight loss benefits, which has led to shortages. Ozempic was originally approved by the FDA to treat people with Type 2 diabetes- who risk serious health consequences without medication. LOS ANGELES, CALIFORNIA - APRIL 17: In this photo illustration, boxes of the diabetes drug Ozempic rest on a pharmacy counter on Apin Los Angeles, California. There’s nothing on the drugs’ labels that specifically cautions that gastroparesis may occur. So far, extreme and unrelenting cases like these are believed to be rare, and they may be a result of the drug unmasking or worsening an existing “slow stomach.” Doctors say people can have a silent condition called delayed gastric emptying and not know it. Vomiting under anesthesia sometimes causes food and stomach acid to get into the lungs, which can cause pneumonia and other problems after surgery. The US Food and Drug Administration said it has received reports of people on the drugs experiencing stomach paralysis that sometimes has not resolved by the time it’s reported.Īnd last month, the American Society of Anesthesiologists warned that patients should stop these medications a week before surgery because they can increase the risk that people will regurgitate food during an operation, even if they’ve fasted as directed. Wright said she has also been diagnosed with cyclic vomiting syndrome, which causes her to throw up multiple times a day.Įmily Wright lost 80 pounds on Ozempic and now struggles with gastroparesis Courtesy Emily WrightĪllen doesn’t have a diagnosis for her stomach problems but said they started only after she was encouraged by her doctor to take Wegovy to lose weight. She is managing her ongoing nausea and vomiting with a medication called Zofran and prescription probiotics while she waits for more tests in October - the first available appointments she could get with specialists.ĭoctors say that more cases like these are coming to light as the popularity of the drugs soared. Knight and Wright have been diagnosed with severe gastroparesis, or stomach paralysis, which their doctors think may have resulted from or been exacerbated by the medication they were taking, Ozempic. If the stomach slows down too much, however, that can cause problems. One of the roles of GLP-1 is to slow the passage of food through the stomach, which helps people feel fuller longer. ![]() ![]() These and other drugs in this family, which includes medications like tirzepatide and liraglutide, work by mimicking a hormone that’s naturally made by the body, GLP-1. The diabetes drug Ozempic, and its sister drug for weight loss, Wegovy, utilize the same medication, semaglutide. ![]() “I’ve almost been off Ozempic for a year, but I’m still not back to my normal,” Wright said. But Wright said she now vomits so frequently that she had to take a leave of absence from her job. Over a year, she said, she lost 80 pounds, which she’s been able to keep off. A low-angle view of a young woman who is weighing herself in a weighing scale Karl Tapales/Moment RF/Getty ImagesĮxperimental drugs aim to surpass weight-loss stars like Ozempic and WegovyĮmily Wright, 38, a teacher in Toronto, started taking Ozempic in 2018.
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